Oxidative stress is essential for KP372-1 induced cell death, that was clogged by overexpressing catalase in the cell largely, or by treating the cell with N-acetylcysteine, an general antioxidant, or Tiron, a cell permeable superoxide scavenger (Figures S5O and S5P). NQO1 catalyzes NAD(P)H-dependent KP372-1 redox cycling and promotes tumor cell death We considered that KP372-1 … Continue reading Oxidative stress is essential for KP372-1 induced cell death, that was clogged by overexpressing catalase in the cell largely, or by treating the cell with N-acetylcysteine, an general antioxidant, or Tiron, a cell permeable superoxide scavenger (Figures S5O and S5P)